CD34+ Cells From Poor Mobilizers Are Qualitatively Equivalent to CD34+ Cells From Good Mobilizers
نویسندگان
چکیده
منابع مشابه
Turning CD34 Non-Mobilizers into Mobilizers: A Case Report Involving Plerixafor (AMD3100).
SUMMARY: OBJECTIVE: In a significant proportion of patients with hematologic malignancies (5-30%) poor mobilization of hematopoietic stem cells (HSC) is observed. This compromises the application of effective and potentially curative high-dose chemotherapy (HDC) treatment. CASE REPORT: Here we report the case of a 38-year-old female patient who was treated for recurrent follicular B-cell non-Ho...
متن کاملHematopoietic Cells − Cells from Cd34 + Ex Vivo Generation of Cd34
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متن کاملHuman CD34+/KDR+ cells are generated from circulating CD34+ cells after immobilization on activated platelets.
OBJECTIVE The presence of kinase-insert domain-containing receptor (KDR) on circulating CD34+ cells is assumed to be indicative for the potential of these cells to support vascular maintenance and repair. However, in bone marrow and in granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood, less than 0.5% of CD34+ cells co-express KDR. Therefore, we studied whether CD34+/KDR+ ...
متن کاملHuman CD34 /KDR Cells Are Generated From Circulating CD34 Cells After Immobilization on Activated Platelets
Objective—The presence of kinase-insert domain-containing receptor (KDR) on circulating CD34 cells is assumed to be indicative for the potential of these cells to support vascular maintenance and repair. However, in bone marrow and in granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood, less than 0.5% of CD34 cells co-express KDR. Therefore, we studied whether CD34 /KDR cel...
متن کاملThe CXCR4 and adhesion molecule expression of CD34+ hematopoietic cells mobilized by “on-demand” addition of plerixafor to granulocyte–colony-stimulating factor
BACKGROUND Granulocyte-colony-stimulating factor (G-CSF) is routinely used for mobilization of hematopoietic stem and progenitor cells preceding autologous transplantation after high-dose chemotherapy in hematologic malignancies. However, due to high mobilization failure rates, alternative mobilization strategies are required. STUDY DESIGN AND METHODS Patients who poorly mobilized CD34+ hemat...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2011
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2010.12.158